Nano-iron oxide particles can be safely used in children with MRI enhancement
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"Children are sensitive because they are still growing, and we do not know anything about the effects of gadolinium on immature organs." Dr. Anne Muehe from the Radiology Department at Stanford University School of Medicine is using a drug that has passed the FDA Approved as an agent for the treatment of anemia - nano iron oxide particles as an MRI contrast agent applied to the safety of children were evaluated. " Nano iron oxide particles are not excreted by the kidneys as gadolinium, but instead are absorbed by the body's bone marrow, liver and spleen and used to synthesize red blood cells."

Between September 2009 and February 2015, a total of 49 pediatric patients aged 5 to 18 years were recruited through collaboration with Stanford University's Lucille Packard Children's Hospital and Oregon Health Sciences University. They received a single dose of nano-iron oxide particles, and under the strict supervision of MRI, including iron ions may cause side effects such as hypotension. The researchers observed only one case of nausea, two cases of clinical symptoms of hypotension may be associated with the use of sedatives. During the follow-up period of 1 month, the subjects had no clinical symptoms and the liver and kidney function were normal.

"This result confirms our hypothesis that nanoscale iron oxide particles can be used as a safe contrast agent for pediatric examinations," Dr. Muehe said." The incidence of severe allergic reactions is still higher than that conventional gadolinium require more long-term prospective trials. "

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